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          服務熱線

          +8610-84928167

          hTGIT

          1. 基本信息

          品系名稱:B6-Tigitem1(hTigit)Vst/Vst

          常用名C57BL/6-Tigit人源化小鼠; Tigit人源化小鼠;Hu-Tigit

          背景C57BL/6NCrl

          毛色黑色


          品系建立

          采用CRISPR-Cas9輔助的方法,將小鼠Tigit基因(T Cell Immunoreceptor With Ig And ITIM Domains)替換為人源Tigit。這樣在Tigit人源化小鼠體內,使用人源Tigit抗體抑制劑時就可以識別,進行相關的藥效或藥物篩選實驗。


          2. 應用領域

          -人源化和癌癥治療

          -免疫治療

          -藥物篩選


          3. 參考文獻

          (1)The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL.Nat Immunol. 2009 Jan;10(1):48-57. doi: 10.1038/ni.1674. Epub 2008 Nov 16.

          (2)Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.Stengel KF, Harden-Bowles K, Yu X, Rouge L, Yin J, Comps-Agrar L, Wiesmann C, Bazan JF, Eaton DL, Grogan JL.Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5399-404. doi: 10.1073/pnas.1120606109. Epub 2012 Mar 15.


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